Down-regulation of the Fetal Stem Cell Factor SOX17 by H33342
نویسندگان
چکیده
منابع مشابه
Down-Regulation of T Cell Function by Heat Shock-Induced Excretory Factor of Leishmania Major
Background: Despite demonstration of molecular and biochemical changes induced by heat shock on Leishmania, the immunological importance of such changes has not been elucidated. Objective: Studying the effect of two excretory factors prepared under heat shock and ambient temperature from Leishmania major on Balb/c splenocytes function. Methods: The parasites were cultured at 25°C and then sub...
متن کاملFetal to Adult Stem Cell Transition: Knocking Sox17 off
What controls the inherent differences between fetal and adult hematopoietic stem cells (HSCs)? In this issue of Cell, Kim et al. (2007) demonstrate in mice that the endodermal transcription factor Sox17 is required for the maintenance of fetal and neonatal but not adult HSCs.
متن کاملSox17 Dependence Distinguishes the Transcriptional Regulation of Fetal from Adult Hematopoietic Stem Cells
Fetal stem cells differ phenotypically and functionally from adult stem cells in diverse tissues. However, little is known about how these differences are regulated. To address this we compared the gene expression profiles of fetal versus adult hematopoietic stem cells (HSCs) and discovered that the Sox17 transcriptional regulator is specifically expressed in fetal and neonatal but not adult HS...
متن کاملdown-regulation of t cell function by heat shock-induced excretory factor of leishmania major
background: despite demonstration of molecular and biochemical changes induced by heat shock on leishmania , the immunological importance of such changes has not been elucidated. objective: studying the effect of two excretory factors prepared under heat shock and ambient temperature from leishmania major on balb/c splenocytes function. methods: the parasites were cultured at 25 ° c and the...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2010
ISSN: 0021-9258
DOI: 10.1074/jbc.m109.082941